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Ivermectin research 121gamers 23 意见 • 2 月前

With Professor Colleen Aldous
Critical appraisal of multidrug therapy in the ambulatory
management of patients with COVID-19 and hypoxemia
Part II: Causal inference using the Bradford Hill criteria

https://www.jstage.jst.go.jp/a....rticle/antibiotics/7

We continue the critical appraisal of three published case series of 119 COVID-19 patients with hypoxemia, treated in the United States, Zimbabwe, and Nigeria with similar ivermectin-based multidrug treatments, to assess the available evidence supporting a causal relationship between treatment and reduction in hospitalizations and mortality. A narrative review was conducted to assess the Bradford Hill criteria for a causal association. We used a previously proposed refinement of the Bradford Hill criteria that reorganized them into three categories of direct, mechanistic, and
parallel evidence. The efficacy of the two most aggressive ivermectin-based
multidrug protocols is supported by the Bradford Hill criteria for temporality,
strength of association, biological gradient, biological plausibility, coherence, consistency, and analogy. The causal relation between the treatment of hypoxemic COVID-19 patients using these protocols and the reduction in hospitalizations and mortality is supported as an inference to the best explanation.

Critical appraisal of multidrug therapy in the ambulatory
management of patients with COVID-19 and hypoxemia
Part I. Evidence supporting the strength of association

https://faculty.utrgv.edu/elef....therios.gkioulekas/p

On March 11, 2020, Coronavirus Disease 2019 (COVID-19), the disease caused by the Severe Acute Respiratory Coronavirus 2 (SARS-CoV-2), was declared a pandemic by the World Health Organization (WHO) [1]. Worldwide, 768,187,096 confirmed cases of COVID-19 and 6,945,714 deaths have been reported to the WHO as of June 21 2023, amounting to an average Case Fatality Rate (CFR) of 0.9% [2]. During 2020, while several governments and public health agencies were focused on contagion control and in-hospital patient care, several medical doctors from all around the world innovated and discovered early outpatient multidrug treatments using several repurposed medications in combination [3–15]. In the United States, several independent efforts coalesced into the formulation of a sequenced multidrug protocol [10, Fig. 3] (hereafter, McCullough protocol), which is based on the pathophysiological understanding of COVID-19 as a triphasic illness with three overlapping phases: (1) viral proliferation; (2) hyperinflammatory cytokine storm (COVID-19 pneumonia); and (3) thrombosis. McCullough’s protocol proposed a combination antiviral therapy for treating the viral proliferation phase, immunomodulators for treating the cytokine storm, and antiplatelet agents and antithrombotics for handling the thrombotic stage, based on risk stratification and how the disease presents in each individual patient. Thus, the McCullough protocol is an algorithmic treatment using sequenced multiple drugs in combination and customized to the individual patient and their response to treatment; no single drug is necessary nor sufficient to achieve treatment efficacy towards reducing hospitalizations and deaths. A recently published update of the McCullough protocol [16, Fig. 3] introduced some adjustments including virucidal nasal washes and oral gargles [17–24]. A large case series of 869 high-risk patients [25, 26], who were treated using an early version of the McCullough protocol, has been compared against population-level and historical controls [27], showing the existence of efficacy with respect to the reduction of mortality and hospitalizations, which is also resilient with respect to random selection bias, provided that patients are treated early enough within the first 3 to 5 days from the onset of illness. Indeed, an earlier study by Fazio et al.[28] showed that the ideal window of opportunity for initiating an effective early outpatient treatment of COVID-19 to prevent hospitalization is approximately within the first 3 days.

Skidamarink (Animated Version) | Super Simple Songs cashinvids 25 意见 • 3 年前

Watch videos from Super Simple in the Super Simple App for iOS! ► http://apple.co/2nW5hPd

Sweet and just a little bit silly, "Skidamarink" is the perfect kids song to say, "I love you!" We hope you enjoy our new animated version of this Valentine's Day favorite.

Listen to Super Simple Songs on Spotify: https://spoti.fi/2ofnaZg
Listen to Super Simple Songs on Apple Music: https://apple.co/2pBcg0j
Or, just ask your smart speaker to play Super Simple Songs!
PARENTS AND TEACHERS: Thank you so much for watching Super Simple Songs with your families and/or students. If your young ones are watching without supervision, we recommend some of the following viewing options:
► SUPER SIMPLE APP -- http://bit.ly/SuperSimpleApp
Be the first to watch new Super Simple videos in the Super Simple App! Ad-free and designed for young learners.
► DOWNLOAD -- http://bit.ly/SuperSimpleShop
Videos from all Super Simple channels are available for purchase at the Super Simple online shop. You can also find some DVDs there.
► YOUTUBE KIDS -- http://bit.ly/You-Tube-Kids
Designed to make it safer and simpler for young ones to watch online video, YouTube Kids includes a suite of parental controls so you can tailor the experience to suit your family’s needs.
► AMAZON VIDEO
Are you an Amazon Prime member? Watch Super Simple videos ad-free on Amazon Prime Video. Just search for “Super Simple.”
► KHAN ACADEMY KIDS -- http://bit.ly/KhanKids-App
Super Simple has partnered with Khan Academy on their latest app designed for preschoolers. You’ll find Super Simple Songs worked into the curriculum throughout the app.
► PLAYKIDS -- http://bit.ly/Play-Kids
Do you have the PlayKids app? You can find many of our Super Simple Songs and programs in the app!

FREE SUPER SIMPLE TEACHING RESOURCES: http://bit.ly/SSFree-Resources

SOCIAL MEDIA:
Super Simple Newsletter Sign Up: http://bit.ly/SuperSimpleSignUp
Facebook: http://bit.ly/SuperSimpleFacebook
Instagram: http://bit.ly/SuperSimpleInsta
Twitter: http://bit.ly/SuperSimpleTwitter
Pinterest: http://bit.ly/SuperSimplePinterest

******
Lyrics:
Skidamarink a dink a dink.
Skidamarink a doo.
I love you.

Skidamarink a dink a dink.
Skidamarink a doo.
I love you.

I love you in the morning.
And in the afternoon.
I love you in the evening.
And underneath the moon.

Skidamarink a dink a dink.
Skidamarink a doo.
I love you.

(Repeat)

*****
Song: Skidamarink
CD: Super Simple Songs 3
Music: Super Simple Learning
Vocals: Ingrid DuMosch DeHaan and Matt Stamm

*****
We're Super Social, too!
Google+: http://google.com/+supersimplesongs
facebook: http://facebook.com/supersimpleofficial
Twitter: http://twitter.com/simplesongs
Pinterest: http://pinterest.com/simplesongs
Instagram: http://instagram.com/supersimpleofficial
Blog: http://supersimplelearning.com/blog

*****
Super Simple Songs® and Super Simple Learning® are registered trademarks of Super Simple Learning, Inc.

*****
Skidamarink by Super Simple Learning

How to Make a Circuit Board (Beginner's Guide) 121gamers 23 意见 • 2 月前

Check out https://jlcpcb.com/HWN to get 1-4 layer PCBs for $2 and free SMD coupons!
Need a board design? Order the PCB in the video! Download the files for free here: https://bit.ly/3CxoTcK
⭐ Support these videos on Patreon ⭐: https://patreon.com/hardwareunknown
Subscribe to Hardware Unknown: https://bit.ly/3qctyxZ

Doing any of these things helps grow the channel, allowing me to make more videos. Thank you for your support. You make all this possible.

------------------------------

Here's how to make your very own custom circuit board/PCB! When we start learning a new skill, we don't know what we don't know. What should you Google search? It's hard to say! This beginner's guide solves that for you even if you know nothing of basic electronics. Follow along and learn from the exact resources I used when discovering my love of electronic design.

Join me.

- Chapters -
00:00 - What We'll Cover
00:38 - Learning Basic Electronics
02:00 - Prototyping on a Breadboard
02:56 - Hand Soldering on Perfboard
04:25 - Learning KiCad
05:38 - Ordering Circuit Boards
07:02 - Project Examples and How to Support the Channel

📚 RESOURCES 📚

#1 Learning basic electronics
Basic Electronics Guide: https://bit.ly/3HzvIOA
The Learning Circuit: https://bit.ly/3Ft8fg1
The Engineering Mindset: https://bit.ly/3FrqxOQ
learnelectronics: https://bit.ly/3kSv6Kd
GreatScott!: https://bit.ly/3qRJwy3

- Arduino -
Core Electronics' Arduino Workshop: https://bit.ly/3FsC8gC
How To Mechatronics: https://bit.ly/3HASuFT
DroneBot Workshop: https://bit.ly/3kQ7kyG

#2 Prototyping on a breadboard
Science Buddies' How to Use a Breadboard: https://youtu.be/6WReFkfrUIk

#3 Hand soldering on perfboard
Adafruit's Soldering Overview: https://youtu.be/QKbJxytERvg
wermy's Soldering Crash Course: https://youtu.be/6rmErwU5E-k

#4 Learning KiCad
KiCad download: https://www.kicad.org/
Getting to Blinky 5.0 website (recommended): https://bit.ly/30GjgvD
Getting to Blinky 5.0 YouTube playlist: https://bit.ly/3qQblqt

⭐ #5 Ordering circuit boards from JLCPCB ⭐
JLCPCB website: https://jlcpcb.com/HWN
How to generate Bill of Materials (BOM) and part orientation (CPL) files: https://bit.ly/3Ccl1xx
Need a board design? Order the PCB in the video! Download the gerber ZIP, BOM, and CPL files for free here: https://bit.ly/3CxoTcK

- Some of my projects -
IKEA Bekant Desk Automater: https://youtu.be/PAwVm_qNaAs
Cornhole Boards With Reactive Lights/Sound: https://youtu.be/Ilx1WQxmtjk
Quad-Barrel Air Cannon Helps Me Make Pasta Sauce: https://youtu.be/a1XdPYEsf_o
How to Make a Quad-Barrel Air Cannon: https://youtu.be/Rig2nZphQ7A
The Focus Flower: https://youtu.be/W6ikFC172cY

🛠️ EQUIPMENT/PARTS I USED 🛠️

As an Amazon Associate I earn from qualifying purchases through links in my descriptions and comments. This helps me finance future videos at no additional cost to you. If you choose to support me in this way, thank you.

- Prototyping -
Breadboards + jumper wires: https://amzn.to/3c8YOWq
Breadboards only: https://amzn.to/3F8WJWY
Jumper wires only: https://amzn.to/3pwa4UK
Multimeter: https://amzn.to/3naf4No

- Components -
Resistors: https://amzn.to/2UIjCPl
Electrolytic capacitors: https://amzn.to/3kvHrDW
Ceramic capacitors: https://amzn.to/3qBS8Zl
Diodes: https://amzn.to/3xUKlX8
LEDs: https://amzn.to/3coxNi6
Signal MOSFETs: https://amzn.to/3Ef6S4i
Power MOSFETs: https://amzn.to/2TVselb
Power jacks: https://amzn.to/3y0absD
Power plugs: https://amzn.to/3A6d11t
Push buttons: https://amzn.to/3jpG6iv
Terminals: https://amzn.to/3A0UTpu
Toggle switches: https://amzn.to/3gR3ELo
M2.5 threaded inserts: https://amzn.to/3A5zdsl

- Arduino -
Arduino Uno clone: https://amzn.to/3nvv8cD
Arduino Uno starter kit: https://amzn.to/3Cry3qZ
Arduino Nano clone: https://amzn.to/3jcLDsw

- Power -
12V 3000mAh battery: https://amzn.to/3zZOP0n
12V 2A power supply: https://amzn.to/3nnW4Kj

- Soldering Tools -
Hakko FX-888D soldering iron: https://amzn.to/3dfthmY
Soldering tip set: https://amzn.to/3HhU9zX
3D-printed insert tip set: https://amzn.to/3c907EO
Helping hands: https://amzn.to/3jcJ89A
Fan: https://amzn.to/3A4jnhy
Diagonal cutters: https://amzn.to/2U7tNg4
Wire strippers: https://amzn.to/3qrEwhr
Solder sucker: https://amzn.to/3CfSCH1
Pliers: https://amzn.to/3qz3k98
Heat gun: https://amzn.to/3HkkIVd

- Soldering Consumables -
Solder: https://amzn.to/3xRtNPP
Perfboard: https://amzn.to/3vX3NRO
22AWG solid wire: https://amzn.to/3haZlJz
22AWG stranded wire: https://amzn.to/3dkN4Bc
Heat shrink: https://amzn.to/3A1sxeF
Headers: https://amzn.to/3gY1hGL
Isopropyl alcohol: https://amzn.to/3wNK9JR
Isopropyl dispenser: https://amzn.to/2YP19Da
Flux paste: https://amzn.to/2YNouVM

😃 Attributions 😃

Music (in order, all by Patrick Patrikios):

Dynamite
Know Myself
We March Together
Running Out

Graphics and Footage:

Lightning bolt
https://bit.ly/30nUmR1
Artist: https://bit.ly/3C8MujP
Public domain

AC/DC Logo
https://logos-world.net/ac-dc-logo/
Included in accordance with 17 U.S. Code § 107: Fair use