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Ivermectin and mebendazole, 84% benefit in cancer 121gamers 23 意见 • 2 月前

Ivermectin and Mebendazole in Cancer Patients

https://zenodo.org/records/19455636

The Clinical Benefit Ratio

Complete Response + Partial Response + Stable Disease / Total Patients

(CBR) was 84.4%

Overall, it is estimated that annual costs of standard chemotherapies average $111,000 per year.

Background: Drug repurposing offers a pathway to identify accessible, low-toxicity cancer therapies.

Ivermectin and mebendazole have demonstrated multi-target anti-cancer activity.

This paper evaluates real-world patient-reported outcomes, safety, and adherence in a cohort of cancer patients utilizing this combination protocol.

Methods:

Prospective observational cohort of 197 cancer patients,

who were prescribed ivermectin and mebendazole off-label through telemedicine (platform by licensed U.S. healthcare providers)

Participants received compounded oral capsules containing 25 mg ivermectin and 250 mg mebendazole.

Data were collected via voluntary, standardized digital surveys at baseline and at approximately 6-month follow-up.

Of the initial cohort (N = 197), baseline characteristics, including cancer type and disease status, were assessed.

A total of 122 participants completed the follow-up survey (61.9% response rate)

Results:

Mean age of 67 years, (52.3% male, 47.7% female).

Cancer types included
Prostate 27.9%
Breast 18.3%
Lung 8.6%
Colon 5.1%
Urologic 4.6%
Pancreatic 3.0%
Liver 2.5%
Gynaecologic 2.5%
Hematologic 2.5%
Median duration since initial diagnosis, 1.2 years

37.1% experiencing active disease progression.

6-month follow-up

Medication adherence, 86.9%

Full initial 90-capsule ivermectin-mebendazole prescription.

The Clinical Benefit Ratio

Complete Response + Partial Response + Stable Disease / Total Patients

(CBR) was 84.4%

Notably, 48.4% of cohort, strongest positive outcomes:

Regression, 15.6%

No current evidence of disease (NED), 32.8%

Disease stability, 36.1%

Disease progression, 15.6%

No significant dose-response association was observed for cancer outcomes (p = 0.91),

without a clear dose-response gradient for efficacy.

Side effects

Mild side effects (primarily gastrointestinal), 25.4%

(93.6% of those affected continued treatment through minor dose adjustments)

Concurrent conventional therapies

Chemotherapy, 27.9%
Radiation therapy, 21.3%
Surgery, 19.7%

Adjunctive interventions such as supplement use, 49.2%
Dietary modification, 37.7%

Conclusions: In this prospective real-world cohort, the combination of ivermectin and mebendazole was associated with high rates of self-reported clinical benefit, with nearly half of participants reporting tumours regression or no current evidence of disease across a heterogeneous population of cancer patients.

These findings provide a compelling clinical signal that these well-tolerated, repurposed agents may offer therapeutic benefit.

However, observational design, reliance on self-reported outcomes, and potential for selection bias and uncontrolled confounding, these findings should be interpreted as hypothesis-generating.

Urgent prospective, randomized, placebo-controlled clinical trials

Validate these observations and further define optimal dosing strategies.

Mechanism (pharmacodynamics)

Ivermectin and mebendazole are antiparasitic agents,

demonstrated highly promising anti-cancer activity.

Ivermectin

Shown to exert over 14 distinct anti-cancer mechanisms across more than 12 cancer types,

inhibiting cancer cell proliferation, metastasis, angiogenesis, mitochondrial function.

Has demonstrated excellent safety in cancer patients (including those actively undergoing chemotherapy)

Ivermectin and mebendazole selectively target cancer stem cells

Mebendazole

Microtubule disruption, leading to effective cell cycle arrest

Potent induction of apoptosis

Significant inhibition of tumour growth

Inhibition of angiogenesis

Disruption of glucose uptake

When used together

Target non-overlapping pathways, resulting in synergistic tumour regression,

cancer stem cell depletion, and reversal of multidrug resistance in multiple in vitro and in vivo models

Biodistribution, ivermectin and mebendazole document excellent tissue penetration

🔥Post Graduate Program In Full Stack Web Development: https://www.simplilearn.com/pgp-full-stack-web-development-certification-training-course?utm_campaign=PHPFCAug24&utm_medium=DescriptionFirstFold&utm_source=youtube
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This PHP full course or php tutorial for beginners video covers all the key concepts of PHP including an introduction to PHP, hello world in PHP, OOP in PHP, PHP with MySQL, PHP form validation, PHP get and post methods, PHP crud operations, PHP form login, PHP vs Python, PHP rest API, PHP registration for VSCode, PHP programming, along with most important PHP interview questions.

00:00:00 PHP full course
00:10:18 PHP Using Xampp
00:13:39 Hello World in PHP
00:17:43 PHP Programming Concepts
00:59:38 OOPs in PHP
01:25:06 PHP Extenssion for VSCode
01:32:44 PHP GET and POST Method
01:47:16 PHP with MySQL tutorial
02:09:22 PHP Form Validation
02:39:22 PHP CRUD Operations
03:15:13 PHP Registration Form
03:44:01 PHP Login Form
03:56:12 PHP REST API
04:11:46 PHP Web Development Tutorial
05:05:57 PHP Ecommerce Website
05:46:54 PHP Interview Questions

🔥Explore our FREE Courses with Completion Certificate: https://www.simplilearn.com/skillup-free-online-courses?utm_campaign=PHPFCAug24&utm_medium=Description&utm_source=youtube

✅Subscribe to our Channel to learn more about the top Technologies: https://bit.ly/2VT4WtH

⏩ Check out our PHP training videos playlist: https://www.youtube.com/watch?v=KBT2gmAfav4&list=PLEiEAq2VkUUIjP-QLfvICa1TvqTLFvn1b

#PHPFullCourse #PHPForBeginners #PHPTutorialForBeginnersFull #PHPFullTutorial #LearnPHP #PHP #PHPForBeginners #PHPForBeginners #PHPTutorial #PHPTutorialForBeginners #Simplilearn

Introduction to PHP:
Despite being an old language, PHP still comprises 79.8% of all web applications that nearly translates to 20 million websites and 2 million web servers. According to zdnet.com, the demand for PHP developers has also massively increased to 834% since January 2020. PHP stands for Hypertext Preprocessor. It is an open-source server-side scripting language used for dynamic web development and can be embedded into HTML codes.

Some of the major benefits of using PHP are:
1. It is an open-source language. This means that PHP is freely available to use and implement.
2. It is an easy-to-learn language. Since it is very similar to how HTML codes are written, it is easy to understand and implement.
3. It is highly compatible since it can be integrated with multiple programming languages such as HTML, Javascript and supports different databases like MySQL, PostgreSQL, Oracle, etc.
4. It is platform-independent, which means that applications developed using PHP can run in any environment.
5. It has a large community of developers. Programming is all about helping and being helped; hence a large community would mean more help.
6. It is regularly updated and hence works well with the latest technologies.
7. Moving further, let's look at the differences between PHP and other server-side scripting languages.

To learn more about PHP, check our Full Stack Web Developer program: https://www.simplilearn.com/full-stack-web-developer-mean-stack-certification-training?utm_campaign=PHPFCAug24&utm_medium=Description&utm_source=youtube

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This program will advance your career as a MEAN stack developer. You’ll learn top skills such as MongoDB, Express.js, Angular, and Node.js (“MEAN”), plus GIT, HTML, CSS, and JavaScript to build and deploy interactive applications and services. This Full Stack MEAN Developer program provides complete knowledge of software development and testing technologies such as JavaScript, Node.js, Angular, Docker, and Protractor. You'll build an end-to-end application, test and deploy code, and store data using MongoDB.

Key Features:
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✅ 270 hours of in-depth training
✅ 150 hours of instructor-led training
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✅ 10 lesson-end & 4 phase-end projects
✅Choose from 4 industry-aligned capstone projects

For more updates on courses and tips follow us on:
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- Twitter: https://twitter.com/simplilearn
- LinkedIn: https://www.linkedin.com/company/simplilearn/
- Website: https://www.simplilearn.com
- Instagram: https://www.instagram.com/simplilearn_elearning
- Telegram Mobile: https://t.me/simplilearnupdates
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Get the Simplilearn app: https://simpli.app.link/OlbFAhqMqgb

🔥🔥 Interested in Attending Live Classes? Call Us: IN - 18002127688 / US - +18445327688

How to Make a Circuit Board (Beginner's Guide) 121gamers 23 意见 • 2 月前

Check out https://jlcpcb.com/HWN to get 1-4 layer PCBs for $2 and free SMD coupons!
Need a board design? Order the PCB in the video! Download the files for free here: https://bit.ly/3CxoTcK
⭐ Support these videos on Patreon ⭐: https://patreon.com/hardwareunknown
Subscribe to Hardware Unknown: https://bit.ly/3qctyxZ

Doing any of these things helps grow the channel, allowing me to make more videos. Thank you for your support. You make all this possible.

------------------------------

Here's how to make your very own custom circuit board/PCB! When we start learning a new skill, we don't know what we don't know. What should you Google search? It's hard to say! This beginner's guide solves that for you even if you know nothing of basic electronics. Follow along and learn from the exact resources I used when discovering my love of electronic design.

Join me.

- Chapters -
00:00 - What We'll Cover
00:38 - Learning Basic Electronics
02:00 - Prototyping on a Breadboard
02:56 - Hand Soldering on Perfboard
04:25 - Learning KiCad
05:38 - Ordering Circuit Boards
07:02 - Project Examples and How to Support the Channel

📚 RESOURCES 📚

#1 Learning basic electronics
Basic Electronics Guide: https://bit.ly/3HzvIOA
The Learning Circuit: https://bit.ly/3Ft8fg1
The Engineering Mindset: https://bit.ly/3FrqxOQ
learnelectronics: https://bit.ly/3kSv6Kd
GreatScott!: https://bit.ly/3qRJwy3

- Arduino -
Core Electronics' Arduino Workshop: https://bit.ly/3FsC8gC
How To Mechatronics: https://bit.ly/3HASuFT
DroneBot Workshop: https://bit.ly/3kQ7kyG

#2 Prototyping on a breadboard
Science Buddies' How to Use a Breadboard: https://youtu.be/6WReFkfrUIk

#3 Hand soldering on perfboard
Adafruit's Soldering Overview: https://youtu.be/QKbJxytERvg
wermy's Soldering Crash Course: https://youtu.be/6rmErwU5E-k

#4 Learning KiCad
KiCad download: https://www.kicad.org/
Getting to Blinky 5.0 website (recommended): https://bit.ly/30GjgvD
Getting to Blinky 5.0 YouTube playlist: https://bit.ly/3qQblqt

⭐ #5 Ordering circuit boards from JLCPCB ⭐
JLCPCB website: https://jlcpcb.com/HWN
How to generate Bill of Materials (BOM) and part orientation (CPL) files: https://bit.ly/3Ccl1xx
Need a board design? Order the PCB in the video! Download the gerber ZIP, BOM, and CPL files for free here: https://bit.ly/3CxoTcK

- Some of my projects -
IKEA Bekant Desk Automater: https://youtu.be/PAwVm_qNaAs
Cornhole Boards With Reactive Lights/Sound: https://youtu.be/Ilx1WQxmtjk
Quad-Barrel Air Cannon Helps Me Make Pasta Sauce: https://youtu.be/a1XdPYEsf_o
How to Make a Quad-Barrel Air Cannon: https://youtu.be/Rig2nZphQ7A
The Focus Flower: https://youtu.be/W6ikFC172cY

🛠️ EQUIPMENT/PARTS I USED 🛠️

As an Amazon Associate I earn from qualifying purchases through links in my descriptions and comments. This helps me finance future videos at no additional cost to you. If you choose to support me in this way, thank you.

- Prototyping -
Breadboards + jumper wires: https://amzn.to/3c8YOWq
Breadboards only: https://amzn.to/3F8WJWY
Jumper wires only: https://amzn.to/3pwa4UK
Multimeter: https://amzn.to/3naf4No

- Components -
Resistors: https://amzn.to/2UIjCPl
Electrolytic capacitors: https://amzn.to/3kvHrDW
Ceramic capacitors: https://amzn.to/3qBS8Zl
Diodes: https://amzn.to/3xUKlX8
LEDs: https://amzn.to/3coxNi6
Signal MOSFETs: https://amzn.to/3Ef6S4i
Power MOSFETs: https://amzn.to/2TVselb
Power jacks: https://amzn.to/3y0absD
Power plugs: https://amzn.to/3A6d11t
Push buttons: https://amzn.to/3jpG6iv
Terminals: https://amzn.to/3A0UTpu
Toggle switches: https://amzn.to/3gR3ELo
M2.5 threaded inserts: https://amzn.to/3A5zdsl

- Arduino -
Arduino Uno clone: https://amzn.to/3nvv8cD
Arduino Uno starter kit: https://amzn.to/3Cry3qZ
Arduino Nano clone: https://amzn.to/3jcLDsw

- Power -
12V 3000mAh battery: https://amzn.to/3zZOP0n
12V 2A power supply: https://amzn.to/3nnW4Kj

- Soldering Tools -
Hakko FX-888D soldering iron: https://amzn.to/3dfthmY
Soldering tip set: https://amzn.to/3HhU9zX
3D-printed insert tip set: https://amzn.to/3c907EO
Helping hands: https://amzn.to/3jcJ89A
Fan: https://amzn.to/3A4jnhy
Diagonal cutters: https://amzn.to/2U7tNg4
Wire strippers: https://amzn.to/3qrEwhr
Solder sucker: https://amzn.to/3CfSCH1
Pliers: https://amzn.to/3qz3k98
Heat gun: https://amzn.to/3HkkIVd

- Soldering Consumables -
Solder: https://amzn.to/3xRtNPP
Perfboard: https://amzn.to/3vX3NRO
22AWG solid wire: https://amzn.to/3haZlJz
22AWG stranded wire: https://amzn.to/3dkN4Bc
Heat shrink: https://amzn.to/3A1sxeF
Headers: https://amzn.to/3gY1hGL
Isopropyl alcohol: https://amzn.to/3wNK9JR
Isopropyl dispenser: https://amzn.to/2YP19Da
Flux paste: https://amzn.to/2YNouVM

😃 Attributions 😃

Music (in order, all by Patrick Patrikios):

Dynamite
Know Myself
We March Together
Running Out

Graphics and Footage:

Lightning bolt
https://bit.ly/30nUmR1
Artist: https://bit.ly/3C8MujP
Public domain

AC/DC Logo
https://logos-world.net/ac-dc-logo/
Included in accordance with 17 U.S. Code § 107: Fair use

Throw away your Allergy Meds (Easy Herbal Allergy Remedy that really Works) 121gamers 23 意见 • 2 月前

It's time to toss your over-the-counter allergy medication and start using something that's actually good for your body! Learn how with this home remedy for allergies.

For the full step-by-step tutorial and any links mentioned, visit the blog post here: https://homesteadingfamily.com..../easy-home-remedy-fo

SUPPLIES MENTIONED:

- Capsule-It Machine: https://homesteadingfamily.com/capsule-machine
- Organic Alfalfa: https://homesteadingfamily.com/fht-alfalfa
- Organic Nettles: https://homesteadingfamily.com/fht-nettle

~~~~~~~~~~~~~~~

MORE ABOUT US!

WELCOME! We're so glad you're here! We are Josh and Carolyn Thomas. Together with our eleven children, we are The Homesteading Family where we’re living a self-sustainable life in beautiful North Idaho. Let us welcome you and show you a bit about us here: http://bit.ly/HFWelcomeVideo

Grow, Preserve & Thrive with us!
Visit us on our blog: https://www.homesteadingfamily.com
Facebook at https://www.facebook.com/homesteadingfamily
Instagram: https://instagram.com/homesteadingfamily
Rumble: https://rumble.com/HomesteadingFamily

A few highlights you don't want to miss are our FREEBIES!!

Healthy Healing at Home – Learn how to confidently use herbal medicine in your home with this FREE 4 video workshop: https://homesteadingfamily.com/HHHyt

Your Best Loaf – A Free 4 video workshop teaching you how to make great bread at home, every time, regardless of the recipe you are using: https://homesteadingfamily.com/free-bread-workshop

Meals on Your Shelf – Can along with me! Learn to can and put jars of a delicious meal on your pantry shelf with this FREE video series: https://homesteadingfamily.com/MOYS-free-workshop

FREE PDF DOWNLOADS:
- Homesteading Family's Favorite Holiday Recipes - Grab all of our family’s favorite holiday recipes. https://homesteadingfamily.com..../free-holiday-recipe
- 5 Steps to a More Self-Sufficient Life - Simple steps anyone can take wherever they are to start a more self-sufficient lifestyle. https://homesteadingfamily.com/5StepsYT
- Thrive Wellness Checklist - A simple guide for healthy living: https://homesteadingfamily.com/TWC_YT
- Permaculture for Your Homestead- An introduction to permaculture with some strategies for applying it to one’s homestead and garden.
https://homesteadingfamily.com/PFYH_YT
- Carolyn’s Cottage Garden herb list - Carolyn’s favorite herbs for growing at home.
https://homesteadingfamily.com/CGHL_YT
- Carolyn’s Make-Ahead Breakfast Casseroles - These easy casseroles are a life-saver for busy weeks! https://homesteadingfamily.com/MABC_YT
- Your FREE Guide to Preserving Eggs - Grab your guide to preserving eggs with multiple methods. https://homesteadingfamily.com/Eggs_YT
- 5 Steps to a Healthy Garden - Get an explanation of what makes healthy soil and 5 steps you can take to improve your garden. https://homesteadingfamily.com/5StepsGardenYT
- Save the Crumbs- Several Recipes for using bread leftovers, a less committal entry to bread than the workshop. https://homesteadingfamily.com/STC_YT
- Fearless Fermenting- A simple guide on basic lacto-ferments. https://homesteadingfamily.com/FF_YT
- Fermenting Tomatoes - Easiest and fastest tomato preservation: https://homesteadingfamily.com/FT_YT
- Preserving Culinary Herbs - Downloadable, step-by-step directions to drying, freezing, and salting culinary herbs. https://homesteadingfamily.com/PCH_YT
- Render Your Own Lard - Grab these easy instructions on how to render your own lard. https://homesteadingfamily.com/RYL_YT
- Grandma Lynn's Blueberry Buckle - A delicious dessert anytime of year: https://homesteadingfamily.com/BB_YT

Ever After - Reveille GTQUST0TSLEGYIGJ This Is Love - Alsever Lake BW7KPLUGHIG4DKV3 Morning Sunshine - LNDÖ MIHMFWVMVC45MBVO Chicken Pickin - BENSON USHW8ZWR6KKYP9IX Jaunty - Brandon Adams IKCMTEWHLJJOVRLZ Times Like These - Andrew Galucki NLD1ODBWO9FDIHT1

#allergyseason #allergyremedy #allergyrelief