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Andy Burnham has arrived in Kyiv for his first foreign visit as UK prime minister, where it is expected he will hand over blueprints so Ukraine can build its own long-range missiles.
It comes as the UK government has agreed to allow defence company MBDA to declassify information on UK components for the long-range Scalp missile – the French equivalent of the UK's Storm Shadow.
The prime minister will also chair his first meeting of the "coalition of the willing", set up by the UK and France under his predecessor, Sir Keir Starmer.
Last week, Moscow warned of "consequences" over the use of British drones by Ukraine in its recent ramping up of strikes on Russian infrastructure.
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#Ukraine #Politics #BBCNews
If you’ve ever opened Framer and thought, “what even is a frame or a stack?” — this video is for you.
In this quick beginner tutorial, I’ll walk you through the basics of Framer — from understanding frames and stacks to how they work together to build clean, responsive website layouts (without touching code!).
You’ll learn:
✨ What frames and stacks actually mean
✨ How to structure your Framer canvas like a pro
✨ Simple layout tips to keep your designs consistent
✨ How to make your site responsive the easy way
Join the Patreon community here for weekly exclusive graphic design tutorials and to connect with other creatives!!!
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#graphicdesign #framer #webdesign
এমপি আনার হত্যা মামলার তদন্ত কর্মকর্তাকে বদলি যে কারণে
#mpanar #mpanwarulazim #db #dbharun #dbsaidur #banglanews #news #ekattortv
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Bunnies being cute - Funny and Cute Baby Bunny Rabbit - Cute Baby animals
Please Subscribe to watching more Cute Videos: Cute Animal, Cute Dog, Cat and Babies...
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Bunnies being cute - Bunny side of TikTok
Cute baby animals Videos Compilation cute moment of the animals - Cutest Animals
Funny and Cute Baby Bunny Rabbit Videos - Baby Animal Video Compilation (2021)
The cause of Thomas Kingston’s death has been revealed at an inquest opening at Gloucestershire Coroner’s Court.
The husband of Prince and Princess Michael of Kent’s daughter, Lady Gabriella Kingston, died from a “traumatic head wound” and a gun was found near Mr Kingston’s body in an outbuilding at his parents' home in the Cotswolds.
The court heard that the 45-year-old died on February 25th.
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In this part of the course, you will learn how to insert data into the database. Different command lines in SQL and basic select queries in SQL. In the previous tutorial, you have already learned about different relations and foreign keys in SQL.
To learn the full course at just $15, visit https://goo.gl/1MdPF7.
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Hell is a real place, and God loved you so much that He came up with a way to save you from it.
Hear more about God’s plan of salvation in this 1983 Billy Graham sermon from Sacramento, California. Watch more #MondayNightClassics every Monday at 8 p.m. EDT.
CONNECT with the Billy Graham Evangelistic Association:
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http://www.mormonchannel.org/films
Thomas, who had doubted, saw the power, majesty, and love of Jesus Christ. Faith in Christ will help people to face their challenges. http://mormonchannel.org/films
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The Church of Jesus Christ of Latter-day Saints
This experiment is not included in the MEL Chemistry subscription–we just love to show you the beauty of chemistry💙
For cool and safe experiments to do at home sign up to MEL Science here: https://goo.gl/ZK6dpv
It’s easy to make the simplest type of cement yourself. In this experiment, we’ll prepare a mixture which you can use to make a little house, for example for a dog.
Safety precautions
Wear a protective mask, gloves and glasses, and work in a well-ventilated room.
Warning! Only under adults supervision.
Reagents and equipment:
* building lime (calcium oxide, 100 g);
* sand (300 g);
* water (100-150 ml);
* deep container for mixing;
* trowel;
* bricks.
Step-by-step instructions
Mix the building lime with water. Gradually add sand and stir thoroughly. We get a simple cement mixture. Apply it to bricks and leave for a week. The bricks are stuck together!
Processes description
In the reaction of calcium oxide with water, calcium hydroxide forms.
СаО + Н₂О = Са(ОН)₂
In air, calcium hydroxide reacts with carbon dioxide with the formation of durable calcium carbonate, which envelops and sticks the sand particles together
Са(ОН)₂ + СО₂ = СаСО₃ + Н₂О
Evy Poumpouras is a former U.S. Secret Service Special Agent and multi-media journalist. She is also the co-host of Bravo TV's series ‘Spy Games’ and author of the best-selling memoir, ‘Becoming Bulletproof’.
00:00 Intro
02:22 My Mission To Unlock People's Potential
05:05 How You Became A Secret Service Officer
10:43 How To Get Someone To Do What You Want Them To
13:10 When You Listen To Someone They Like You More
14:34 You Need To Know About Them And Then You Can Start Asking The Right Questions
18:18 How To Get Others To Respect You
22:59 Is It Your Ego Or Have Your Boundaries Being Broken?
26:49 How To Build Confidence
29:34 The Different Versions Of Ourselves We Create
32:49 What I Learnt About Leadership From Working With 4 US Presidents
35:47 I Was In The Room When US Presidents Would Make Tough Decisions
38:36 My First Day Working For George Bush
41:07 Secret Service Training: Only 1% Make It Through
44:16 The 1% Of People That Became Part Of The Secret Service
46:06 How Can You Tell If Someone Is Lying To You?
48:16 Who's The Biggest Liar You've Met?
50:54 Signs They're Lying To You
52:59 What Your Body Language Reveals About You
01:00:19 Do Men Struggle With Strong Women?
01:01:00 What Advice Would You Give Your Daughter Become A Resilient Person
01:04:37 What Do You Work Out Your Mind And Body
01:07:19 What Was The Scariest Day Of Your Career?
01:12:28 How Was Your Mental Health During Your Career?
01:17:48 Discrimination In The Secret Service
01:19:39 How To Be Heard And Respected
01:25:51 Why You Need To Take Personal Responsibility
01:33:48 The Addiction To Being A Victim
01:35:02 Identifying Victims That Don't Want To Change
01:39:47 Undercover Missions
01:45:24 Discrimination In The Job
01:50:58 Labelling Yourself Can Affect The Way You See Yourself
You can purchase Evy’s book, ‘Becoming Bulletproof’, here: https://amzn.to/3yOiwFN
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Ivermectin and Mebendazole in Cancer Patients
https://zenodo.org/records/19455636
The Clinical Benefit Ratio
Complete Response + Partial Response + Stable Disease / Total Patients
(CBR) was 84.4%
Overall, it is estimated that annual costs of standard chemotherapies average $111,000 per year.
Background: Drug repurposing offers a pathway to identify accessible, low-toxicity cancer therapies.
Ivermectin and mebendazole have demonstrated multi-target anti-cancer activity.
This paper evaluates real-world patient-reported outcomes, safety, and adherence in a cohort of cancer patients utilizing this combination protocol.
Methods:
Prospective observational cohort of 197 cancer patients,
who were prescribed ivermectin and mebendazole off-label through telemedicine (platform by licensed U.S. healthcare providers)
Participants received compounded oral capsules containing 25 mg ivermectin and 250 mg mebendazole.
Data were collected via voluntary, standardized digital surveys at baseline and at approximately 6-month follow-up.
Of the initial cohort (N = 197), baseline characteristics, including cancer type and disease status, were assessed.
A total of 122 participants completed the follow-up survey (61.9% response rate)
Results:
Mean age of 67 years, (52.3% male, 47.7% female).
Cancer types included
Prostate 27.9%
Breast 18.3%
Lung 8.6%
Colon 5.1%
Urologic 4.6%
Pancreatic 3.0%
Liver 2.5%
Gynaecologic 2.5%
Hematologic 2.5%
Median duration since initial diagnosis, 1.2 years
37.1% experiencing active disease progression.
6-month follow-up
Medication adherence, 86.9%
Full initial 90-capsule ivermectin-mebendazole prescription.
The Clinical Benefit Ratio
Complete Response + Partial Response + Stable Disease / Total Patients
(CBR) was 84.4%
Notably, 48.4% of cohort, strongest positive outcomes:
Regression, 15.6%
No current evidence of disease (NED), 32.8%
Disease stability, 36.1%
Disease progression, 15.6%
No significant dose-response association was observed for cancer outcomes (p = 0.91),
without a clear dose-response gradient for efficacy.
Side effects
Mild side effects (primarily gastrointestinal), 25.4%
(93.6% of those affected continued treatment through minor dose adjustments)
Concurrent conventional therapies
Chemotherapy, 27.9%
Radiation therapy, 21.3%
Surgery, 19.7%
Adjunctive interventions such as supplement use, 49.2%
Dietary modification, 37.7%
Conclusions: In this prospective real-world cohort, the combination of ivermectin and mebendazole was associated with high rates of self-reported clinical benefit, with nearly half of participants reporting tumours regression or no current evidence of disease across a heterogeneous population of cancer patients.
These findings provide a compelling clinical signal that these well-tolerated, repurposed agents may offer therapeutic benefit.
However, observational design, reliance on self-reported outcomes, and potential for selection bias and uncontrolled confounding, these findings should be interpreted as hypothesis-generating.
Urgent prospective, randomized, placebo-controlled clinical trials
Validate these observations and further define optimal dosing strategies.
Mechanism (pharmacodynamics)
Ivermectin and mebendazole are antiparasitic agents,
demonstrated highly promising anti-cancer activity.
Ivermectin
Shown to exert over 14 distinct anti-cancer mechanisms across more than 12 cancer types,
inhibiting cancer cell proliferation, metastasis, angiogenesis, mitochondrial function.
Has demonstrated excellent safety in cancer patients (including those actively undergoing chemotherapy)
Ivermectin and mebendazole selectively target cancer stem cells
Mebendazole
Microtubule disruption, leading to effective cell cycle arrest
Potent induction of apoptosis
Significant inhibition of tumour growth
Inhibition of angiogenesis
Disruption of glucose uptake
When used together
Target non-overlapping pathways, resulting in synergistic tumour regression,
cancer stem cell depletion, and reversal of multidrug resistance in multiple in vitro and in vivo models
Biodistribution, ivermectin and mebendazole document excellent tissue penetration
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Music: Run to Earth (Soft Background Music)
Artist: Alec Koff
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