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Ivermectin and mebendazole, 84% benefit in cancer 121gamers 42 Views • 6 months ago

Ivermectin and Mebendazole in Cancer Patients

https://zenodo.org/records/19455636

The Clinical Benefit Ratio

Complete Response + Partial Response + Stable Disease / Total Patients

(CBR) was 84.4%

Overall, it is estimated that annual costs of standard chemotherapies average $111,000 per year.

Background: Drug repurposing offers a pathway to identify accessible, low-toxicity cancer therapies.

Ivermectin and mebendazole have demonstrated multi-target anti-cancer activity.

This paper evaluates real-world patient-reported outcomes, safety, and adherence in a cohort of cancer patients utilizing this combination protocol.

Methods:

Prospective observational cohort of 197 cancer patients,

who were prescribed ivermectin and mebendazole off-label through telemedicine (platform by licensed U.S. healthcare providers)

Participants received compounded oral capsules containing 25 mg ivermectin and 250 mg mebendazole.

Data were collected via voluntary, standardized digital surveys at baseline and at approximately 6-month follow-up.

Of the initial cohort (N = 197), baseline characteristics, including cancer type and disease status, were assessed.

A total of 122 participants completed the follow-up survey (61.9% response rate)

Results:

Mean age of 67 years, (52.3% male, 47.7% female).

Cancer types included
Prostate 27.9%
Breast 18.3%
Lung 8.6%
Colon 5.1%
Urologic 4.6%
Pancreatic 3.0%
Liver 2.5%
Gynaecologic 2.5%
Hematologic 2.5%
Median duration since initial diagnosis, 1.2 years

37.1% experiencing active disease progression.

6-month follow-up

Medication adherence, 86.9%

Full initial 90-capsule ivermectin-mebendazole prescription.

The Clinical Benefit Ratio

Complete Response + Partial Response + Stable Disease / Total Patients

(CBR) was 84.4%

Notably, 48.4% of cohort, strongest positive outcomes:

Regression, 15.6%

No current evidence of disease (NED), 32.8%

Disease stability, 36.1%

Disease progression, 15.6%

No significant dose-response association was observed for cancer outcomes (p = 0.91),

without a clear dose-response gradient for efficacy.

Side effects

Mild side effects (primarily gastrointestinal), 25.4%

(93.6% of those affected continued treatment through minor dose adjustments)

Concurrent conventional therapies

Chemotherapy, 27.9%
Radiation therapy, 21.3%
Surgery, 19.7%

Adjunctive interventions such as supplement use, 49.2%
Dietary modification, 37.7%

Conclusions: In this prospective real-world cohort, the combination of ivermectin and mebendazole was associated with high rates of self-reported clinical benefit, with nearly half of participants reporting tumours regression or no current evidence of disease across a heterogeneous population of cancer patients.

These findings provide a compelling clinical signal that these well-tolerated, repurposed agents may offer therapeutic benefit.

However, observational design, reliance on self-reported outcomes, and potential for selection bias and uncontrolled confounding, these findings should be interpreted as hypothesis-generating.

Urgent prospective, randomized, placebo-controlled clinical trials

Validate these observations and further define optimal dosing strategies.

Mechanism (pharmacodynamics)

Ivermectin and mebendazole are antiparasitic agents,

demonstrated highly promising anti-cancer activity.

Ivermectin

Shown to exert over 14 distinct anti-cancer mechanisms across more than 12 cancer types,

inhibiting cancer cell proliferation, metastasis, angiogenesis, mitochondrial function.

Has demonstrated excellent safety in cancer patients (including those actively undergoing chemotherapy)

Ivermectin and mebendazole selectively target cancer stem cells

Mebendazole

Microtubule disruption, leading to effective cell cycle arrest

Potent induction of apoptosis

Significant inhibition of tumour growth

Inhibition of angiogenesis

Disruption of glucose uptake

When used together

Target non-overlapping pathways, resulting in synergistic tumour regression,

cancer stem cell depletion, and reversal of multidrug resistance in multiple in vitro and in vivo models

Biodistribution, ivermectin and mebendazole document excellent tissue penetration

Who is Jesus Hindi ll Billy Graham's Life CHANGING Message Hindi 121gamers 16 Views • 4 years ago

Powerful Message By Billy Graham, Who is Jesus Hindi

Billy Graham message in hindi

Original English Message Link
https://youtu.be/lo28cLs-jJc

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Final Thing That Must Happen Before Jesus Comes https://youtu.be/Xacjlu7YUZE

जैसा बाइबल में लिखा था सब वैसे ही हो रहा है l Hosea Prophecy Revealed https://youtu.be/bz8-YM4pKFs

Jonah Prophecy Revealed l 40 Days Mystery Unfolded https://youtu.be/ulMLr-xv4Ks

Mindblowing Prophetic Sign From Moses Story https://youtu.be/AQIh_XfEk1U

4 Facts About Second Coming of Jesus
https://youtu.be/ReRKM7yERHI

Message That Shook The Wolrd
https://youtu.be/c4FgMqeZU3g

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Note- NOTE: ALL THE IMAGES/PICTURES, VIDEOS, AND MUSIC SHOWN IN THE VIDEO BELONGS TO THE RESPECTED OWNERS AND NOT ME... I AM NOT THE OWNER OF ANY PICTURES SHOWED IN THE VIDEO

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Copyright and 'fair use' disclaimer:
Copyright Disclaimer Under Section 107 of the Copyright Act 1976, allowance is made for "fair use" for purposes such as criticism, comment, news reporting, teaching, scholarship, and research. Fair use is a use permitted by copyright statute that might otherwise be infringing. Non-profit, educational or personal use tips the balance in the favor of fair use.

Our Purpose, when making Motivational and educational videos, is to make quality educational Motivational videos and share these with our viewers.
1》 This video has no negative impact on anyone.
2》This video is also used for Teaching/Motivational purposes.
3》This video is Transformative in Nature.
4》 I ONLY used bits and pieces of videos and photos to get the point across where Necessary.

On This Channel we help Our Christian Brethren to Know about their Faith and Walk accordingly and Warn them of The Disaster coming ahead.

We are not Here to Entertain the goats, we are here to Feed the Sheep of Christ..
We believe in Sola Scriptura, No Personal Revelation......

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Virtual Environment in Python | Python Tutorial - Day #43 121gamers 21 Views • 2 years ago

Python is one of the most demanded programming languages in the job market. Surprisingly, it is equally easy to learn and master Python. This python tutorial for absolute beginners in Hindi series will focus on teaching you python concepts from the ground up.
Access the Playlist: https://www.youtube.com/playli....st?list=PLu0W_9lII9a
Link to the Repl: https://replit.com/@codewithha....rry/43-Day43-Virtual
Join Replit the browser-based IDE used in this course - https://join.replit.com/code-with-harry-100-doc
►Checkout my English channel here: https://www.youtube.com/channe....l/UC7btqG2Ww0_2LwuQx
►Instagram: www.instagram.com/codewithharry

python, C, C++, Java, JavaScript and Other Cheetsheets [++]:
Playlist: https://www.youtube.com/playli....st?list=PLu0W_9lII9a

►Learn in One Video[++]:
Python[15 Hr]: https://www.youtube.com/watch?v=gfDE2a7MKjA&list=PLu0W_9lII9ahKZ42vg2w9ERPmShYbYAB7
Python Advance[3.5 Hr]: https://www.youtube.com/watch?v=61a7UkDO50s&list=PLu0W_9lII9ahKZ42vg2w9ERPmShYbYAB7
Python[1 Hr]: https://www.youtube.com/watch?v=qHJjMvHLJdg&list=PLu0W_9lII9ahKZ42vg2w9ERPmShYbYAB7
Python[2 Hr]: https://www.youtube.com/watch?v=ihk_Xglr164&list=PLu0W_9lII9ahKZ42vg2w9ERPmShYbYAB7
Python[15 Min]:https://www.youtube.com/watch?v=fr1f84rg4Nw&list=PLu0W_9lII9ahKZ42vg2w9ERPmShYbYAB7
JavaScript[1 Hr]: https://www.youtube.com/watch?v=onbBV0uFVpo&list=PLu0W_9lII9ahKZ42vg2w9ERPmShYbYAB7
C[1.3 Hr]-https://www.youtube.com/watch?v=YXcgD8hRHYY&list=PLu0W_9lII9ahKZ42vg2w9ERPmShYbYAB7
php[1 Hr]: https://www.youtube.com/watch?v=xW7ro3lwaCI&list=PLu0W_9lII9ahKZ42vg2w9ERPmShYbYAB7
php[2.3 Hr]:https://www.youtube.com/watch?v=1SnPKhCdlsU&list=PLu0W_9lII9ahKZ42vg2w9ERPmShYbYAB7
php[Project]- https://www.youtube.com/watch?v=-al2bECumKg&list=PLu0W_9lII9ahKZ42vg2w9ERPmShYbYAB7
HTML[30 Min]:https://www.youtube.com/watch?v=E3ByCRqE7Lo&list=PLu0W_9lII9ahKZ42vg2w9ERPmShYbYAB7
CSS[8.5 Hr]:https://www.youtube.com/watch?v=Edsxf_NBFrw&list=PLu0W_9lII9ahKZ42vg2w9ERPmShYbYAB7
CSS[1.4 Hr]:https://www.youtube.com/watch?v=u5-K_ua9sOw&list=PLu0W_9lII9ahKZ42vg2w9ERPmShYbYAB7
Wordpress[3.2 Hr]:https://www.youtube.com/watch?v=GlLRYml8mCY&list=PLu0W_9lII9ahKZ42vg2w9ERPmShYbYAB7
Angular[2 Hr]:https://www.youtube.com/watch?v=0LhBvp8qpro&list=PLu0W_9lII9ahKZ42vg2w9ERPmShYbYAB7
Java[2.3 Hr]:https://www.youtube.com/watch?v=rV_3Lewxx6o&list=PLu0W_9lII9ahKZ42vg2w9ERPmShYbYAB7
Web Scraping[1 Hr]:https://www.youtube.com/watch?v=uufDGjTuq34&list=PLu0W_9lII9ahKZ42vg2w9ERPmShYbYAB7
MongoDB[2 Hr]:https://www.youtube.com/watch?v=oSIv-E60NiU&list=PLu0W_9lII9ahKZ42vg2w9ERPmShYbYAB7
Numpy[1 Hr]:https://www.youtube.com/watch?v=Rbh1rieb3zc&list=PLu0W_9lII9ahKZ42vg2w9ERPmShYbYAB7
Android Dev[12 Hr]- https://www.youtube.com/watch?v=mXjZQX3UzOs
Linux[1 Hr]:https://www.youtube.com/watch?v=_tCY-c-sPZc&list=PLu0W_9lII9ahKZ42vg2w9ERPmShYbYAB7
JQuery[1.1 Hr]:https://www.youtube.com/watch?v=YFlx1C8XwR0&list=PLu0W_9lII9ahKZ42vg2w9ERPmShYbYAB7
Git and GitHub[1.1 Hr]:https://www.youtube.com/watch?v=gwWKnnCMQ5c&list=PLu0W_9lII9ahKZ42vg2w9ERPmShYbYAB7

►Complete course [playlist]:
React: https://www.youtube.com/playli....st?list=PLu0W_9lII9a
Python-https://www.youtube.com/playli....st?list=PLu0W_9lII9a
OOP Python-https://www.youtube.com/playli....st?list=PLu0W_9lII9a
Java:https://www.youtube.com/playli....st?list=PLu0W_9lII9a
JavaScript- https://www.youtube.com/playli....st?list=PLu0W_9lII9a
PHP-https://www.youtube.com/playli....st?list=PLu0W_9lII9a
C-https://www.youtube.com/playli....st?list=PLu0W_9lII9a
C++-https://www.youtube.com/playli....st?list=PLu0W_9lII9a
Git & GitHub-https://www.youtube.com/playli....st?list=PLu0W_9lII9a
Android Dev- https://www.youtube.com/playli....st?list=PLu0W_9lII9a
Python GUI- https://www.youtube.com/playli....st?list=PLu0W_9lII9a
Web Development- https://www.youtube.com/playli....st?list=PLu0W_9lII9a
Python Django:https://www.youtube.com/playli....st?list=PLu0W_9lII9a
Projects Using HTML, CSS & Javascript- https://www.youtube.com/playli....st?list=PLu0W_9lII9a
Data Structure and Algo:https://www.youtube.com/playli....st?list=PLu0W_9lII9a

Follow Me On Social Media
►Website (created using Django Rest & Angular): https://www.codewithharry.com
►Facebook: https://www.facebook.com/CodeWithHarry
►Instagram: https://www.instagram.com/codewithharry/
Twitter: https://twitter.com/CodeWithHarry
Comment "#HarryBhai" if you read this 😉😉

HOW TO MAKE POWDERED SPICES! Make Your Own Seasonings 121gamers 11 Views • 2 years ago

Easily turn fresh Ginger, Garlic, Herbs, Peppers and just about anything into delicious powdered spices! HOMEMADE SPICES FROM SCRATCH are a great way to preserve food and level up your seasoning game!

LEARN HOW TO MAKE FREE NATURAL SKINCARE, HAIRCARE & COSMETICS along with detailed articles and tutorials on my website 👇🏾:
https://www.wholeelise.com/

Did you know you could make your own dried herbs and spices in just a few simple steps? Make your own seasonings and make the most of vegetables like ginger, garlic & peppers in one go!

SUBSCRIBE NOW FOR MORE AWESOME DIYS!
http://www.youtube.com/c/Whole....Elise?sub_confirmati

For even more delicious food recipes, check out this playlist filled with recipes for Plantain Chips, Katsu Sandwiches, Breakfast Muffins, Fried Dumplings & Sweet Potato Roti:
https://www.youtube.com/watch?v=ArEITYjoqso&list=PLq1qjAecpylguJV_ds5T6IxA10FHMI4Pj

Making spices from scratch was something I didn’t even realise was possible! Turns out that not only is it possible but it’s also incredibly easy and you don’t even need fancy equipment! In this tutorial I’ll show you how to dehydrate fresh herbs and vegetables in a regular oven!

But just because you can make powdered spices from fresh ingredients, is it even worth the effort? ABSOLUTELY!

Regular herbs and spices you can buy from the supermarket are complete weak sauce in comparison to homemade spices & seasonings. Once you try it, you’ll wonder how you ever seasoned your food without it!

Not to mention, you’re not limited to standard seasonings and spice blends – if you can dehydrate it, in theory you can make almost any food into a powdered spice! Using this basic technique you can learn how to make your own powdered seasoning out of pretty much anything.
Including scotch bonnet pepper! Seriously this stuff is lethal but oh so good, especially if you’re a lover of spice.

So here’s how to make your own spices from scratch!

RUNNING LOW ON ESSENTIALS?? Check out my playlist for Essential SELF-ISOLATION DIYS:
https://www.youtube.com/playli....st?list=PLq1qjAecpyl

For more natural skincare DIYs, Check out my playlist below for DIYs teaching you how to make your own LOTION, LIP BALM, BODY BUTTER and SUGAR SCRUBS ☺
https://www.youtube.com/playli....st?list=PLq1qjAecpyl

I also have a lot of natural hair care DIYs like HOMEMADE SHAMPOO, NATURAL HAIR GEL & SATIN SCRUNCIES! Get yourself a girl who can do both!
https://www.youtube.com/playli....st?list=PLq1qjAecpyl

Interesting in adopting more plant-based techniques? Get a great introduction to easy Plant-based Basics:
https://www.youtube.com/watch?v=6jF_moktBZc&list=PLq1qjAecpyliEnZcXtkZLmijmV6Y9QBiy

Want to get to know me?
Subscribe:
https://www.youtube.com/channe....l/UCSBplMlcA2bd8m4OZ

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https://www.instagram.com/wholeelise/

#HowToMakePowderedSpices #SpicesFromScratch #HowToMakeSpices